Mpox

Current Outbreak Summary

Update as of February 6. 2025

The mpox virus is classified into 2 main clades, clade I and clade II, with each further subdivided into clade Ia, the newly identified clade Ib, clade IIa, and clade IIb, the clade which was responsible for the 2022 global outbreak. Since the 2022 clade IIb mpox outbreak began, there have been more than 124,753 cases and more than 272 deaths reported in 128 countries, though worldwide reported data likely do not include the most recent outbreaks of clade I in the Africa region. According to the US Centers for Disease Control and Prevention (US CDC) and the World Health Organization (WHO), the US has reported 34,490 mpox cases as of December 31, 2024. The US outbreak has slowed considerably in late 2024 and early 2025, though recent federal communications freeze on the US CDC impacts the confidence in the reported data. With the continued transmission of clade IIb in the US and globally and the increased transmission of clade I and II in the Africa region, experts are concerned that changes in the national and global landscape have the potential to increase health risks for specific US populations.